Prof Vasanth Andrews
MRCOG, FACOG, FRCOG
Accredited Menopause Specialist
Oestrogen isn’t just important for reproductive health—it also plays a critical role in brain function. It supports memory, mood regulation, and even helps protect brain cells from damage.
Here’s how HRT may support your brain:
Supports Memory and Cognitive Function
Several studies suggest that oestrogen may help maintain memory and cognitive sharpness, especially when HRT is started early in menopause.
May Lower the Risk of Dementia
Some research indicates that starting HRT around the time of menopause (rather than years later) could reduce the risk of Alzheimer’s disease. This is known as the timing hypothesis the idea that earlier use of HRT is more beneficial for brain health.
Protects Nerve Cells
Oestrogen has antioxidant and anti-inflammatory effects in the brain. These actions may help protect neurons (nerve cells) from the wear and tear that comes with age and disease.
What Does the Research Say?
While the results are promising, the picture is still evolving. Some key points:
Early use may matter: Starting HRT within 10 years of menopause appears to offer the most brain-protective benefits.
Type and route matter: Some forms of oestrogen (like transdermal patches) may be safer for brain and heart health than others.
Not for everyone: HRT is not recommended solely for dementia prevention, and it’s important to weigh the risks and benefits.
Is HRT Right for You?
The decision to use HRT is personal. If you’re experiencing difficult menopausal symptoms, and you’re concerned about cognitive changes or your long-term brain health, talk to your healthcare provider.
You might be a good candidate for HRT if:
- You’re within 10 years of menopause
- You’re generally healthy
- You’re looking to manage menopausal symptoms
- You want to explore potential added benefits for brain and bone health
Key message from eGynaecologist
Hormone Replacement Therapy is more than just symptom relief—it may also support your brain as you age. While it’s not a cure-all or a guaranteed shield against memory loss, using the right type of HRT at the right time might help protect your cognitive health.
As always, the best decisions about your health are made with your healthcare provider, based on your individual history and needs.
Have more questions about HRT and brain health? Don’t hesitate to ask your gynaecologist or menopause specialist. Your brain—and your future—are worth it.
